| Synthesis of Flurbiprofen via Suzuki Reaction Catalyzed by Palladium Charcoal in Water |
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| 作者姓名： | Gang LU Robert FRANZEN Xiao Jing YU You Jun XU |
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| 作者单位： | Institute of |
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| 基金项目： | We are grateful to Liaoning Natural Science Foundation for the Talent Doctors Fund （No. 20041037） and Magnus Ehrnrooths Foundation of Finland for the financial supports. |
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| 摘 要： | Flurbiprofen 1, an excellent nonsteroidal antiinflammatory drug, was synthesized in 5 steps in 69% overall yield. The key step of constructing the biaryl fragment was successfully achieved via Pd/C-catalyzed Suzuki coupling reaction in water using sodium tetraphenylborate as phenylation reagent.
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| 关 键 词： | 合成 氟比洛芬 Suzuki耦合反应 Pd/C催化剂 四苯硼酸钠 药物合成 |
| 收稿时间： | 2005-09-19 |
Synthesis of Flurbiprofen via Suzuki Reaction Catalyzed by Palladium Charcoal in Water |
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| Gang LU Robert FRANZEN Xiao Jing YU You Jun XU.Synthesis of Flurbiprofen via Suzuki Reaction Catalyzed by Palladium Charcoal in Water[J].Chinese Chemical Letters,2006,17(4):461-464. |
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| Authors: | Gang LU Robert FRANZN Xiao Jing YU You Jun XU |
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| Institution: | Gang LU,Robert FRANZ(E)N,Xiao Jing YU,You Jun XU |
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| Abstract: | Flurbiprofen 1, an excellent nonsteroidal antiinflammatory drug, was synthesized in 5 steps in 69% overall yield. The key step of constructing the biaryl fragment was successfully achieved via Pd/C-catalyzed Suzuki coupling reaction in water using sodium tetraphenylborate as phenylation reagent. |
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| Keywords: | Flurbiprofen Suzuki coupling Pd/C sodium tetraphenylborate |
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