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Synthesis of Tritium and Deuterium Labelled Agmatine
作者姓名:Hong  Xia  HE  Zhi  Bing  ZHENG  Lan  Fu  CHEN  Zhan  Bin  ZHANG  Chun  HU  Song  LI
作者单位:Hong Xia HE1,Zhi Bing ZHENG2*,Lan Fu CHEN2,Zhan Bin ZHANG3,Chun HU1,Song LI2 1 Shenyang Pharmaceutical University,Shenyang 110016 2 Beijing Institute of Pharmacology and Toxicology,Beijing 100850 3 Beijing Normal University,Beijing 100875
摘    要:Agmatine is a promising anti-opioid dependence and relapse drug1~2 discovered and developed by Beijing Institute of Pharmacology and Toxicology, but the physiological role of agmatine in inhibition of tolerance to and dependence on opioid are not well est…

关 键 词:合成      胍基丁胺  比活度  放射化学
收稿时间:2005-10-10

Synthesis of Tritium and Deuterium Labelled Agmatine
Hong Xia HE Zhi Bing ZHENG Lan Fu CHEN Zhan Bin ZHANG Chun HU Song LI.Synthesis of Tritium and Deuterium Labelled Agmatine[J].Chinese Chemical Letters,2006,17(5):587-590.
Authors:Hong Xia HE  Zhi Bing ZHENG  Lan Fu CHEN  Zhan Bin ZHANG  Chun HU  Song LI
Abstract:An efficient procedure for the synthesis of agmatine labelled with tritium and deuterium is reported. The final tritiated product 4 was obtained with a specific activity of 40 Ci/mmol and a radiochemical purity of 95%.
Keywords:Agmatine  labelled compound  synthesis  deuterium  tritium  
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