Sevelamer as an efficient and reusable heterogeneous catalyst for the Knoevenagel reaction in water |
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Authors: | Xian-Liang Zhao ;Ke-Fang Yang ;Yan-Ping Zhang ;Ju Zhu ;Li-Wen Xu |
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Institution: | a School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China;
b Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, China |
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Abstract: | A catalyst system of Sevelamer, a phosphate-binding drug, has been prepared and used in the Knoevenagel reaction of aromatic aldehydes in water to produce substituted electrophilic alkenes. The products were obtained in excellent yields. Several novel, related catalytic systems showed promising catalytic properties for aromatic and heterocyclic aldehydes. The Sevelamer catalyst can be recovered using simple filtration and reused numerous times(up to 15 times) in the aqueous Knoevenagel reaction without any significant lowering of activity. |
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Keywords: | Knoevenagel reaction Sevelamer Recycle Heterogeneous |
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