| Practical and concise synthesis of 2-oxo-3,4,5,6-tetraethoxyazepane from D-glucono-1,5-lactone |
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| 作者姓名： | Yan Jiao Zhi Jie Fang Yu Hua Jiang Bao Hui Zheng Jie Cheng |
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| 作者单位： | School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China |
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| 基金项目： | This work was financially supported by the Graduate Education Innovation Foundation of Nanjing University of Science ＆ Technology （No. 200705）. |
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| 摘 要： | 2-Oxo-3R,4S,5S,6S-tetraethoxyazepane was conveniently synthesized from D-glucono-1, 5-1actone with a yield of 10% overall. The key step of synthetic route-reductive 1,6-cyclization was completed efficiently by using Ph3P to give the expected lactam.
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| 关 键 词： | 亚氨基糖 内酯 合成 有机化学反应 |
Practical and concise synthesis of 2-oxo-3,4,5,6-tetraethoxyazepane from D-glucono-1,5-lactone |
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| Yan Jiao,Zhi Jie Fang,Yu Hua Jiang,Bao Hui Zheng,Jie Cheng.Practical and concise synthesis of 2-oxo-3,4,5,6-tetraethoxyazepane from D-glucono-1,5-lactone[J].Chinese Chemical Letters,2008,19(7):795-796. |
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| Authors: | Yan Jiao Zhi Jie Fang Yu Hua Jiang Bao Hui Zheng Jie Cheng |
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| Institution: | School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China |
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| Abstract: | 2-Oxo-3R,4S,5S,6S-tetraethoxyazepane was conveniently synthesized from D-glucono-1,5-lactone with a yield of 10% overall. The key step of synthetic route-reductive 1,6-cyclization was completed efficiently by using Ph_3P to give the expected lactam. |
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| Keywords: | Azepane Ph3P Reduction Iminosugars Glucono lactone |
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