| Effect of Micelle Composition on Acidic Drugs Separation Behavior by Micellar Electrokinetic Capillary Chromatography |
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| 作者姓名： | Miao WANG Jian Wei YAN Yan Fei LIN Jian De LU* Xiao Yun FU |
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| 作者单位： | Miao WANG1，Jian Wei YAN2，Yan Fei LIN1，Jian De LU1*，Xiao Yun FU1 1Department of Chemistry，Yuquan Campus，Zhejiang University，Hangzhou 310027 2Zhejiang College of Chinese Traditional Medicine，Hangzhou 310053 |
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| 摘 要： | Micellar electrokinetic capillary chromatography (MECC) is a branch of capillary electrophoretic techniques, in which surfactant micelles are added to the electrolyte solution as pseudostationary phase. Separation in MECC is based on electrophoretic mobilities of the analytes when partitioned into micelles1. In this work, four acidic drugs similar in structure with aryl carboxylic acid were separated by MECC. The effects of type of surfactant, such as anionic surfactant SDS, nonionic …
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Effect of Micelle Composition on Acidic Drugs Separation Behavior by Micellar Electrokinetic Capillary Chromatography |
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| Miao WANG,Jian Wei YAN,Yan Fei LIN,Jian De LU*,Xiao Yun FU .Effect of Micelle Composition on Acidic Drugs Separation Behavior by Micellar Electrokinetic Capillary Chromatography[J].Chinese Chemical Letters,2002,13(12). |
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| Authors: | Miao Wang Jian Wei YAN Yan Fei LIN Jian De LU Xiao Yun FU |
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| Abstract: | Micellar electrokinetic capillary chromatography (MECC) separation of four acidic drugs similar in structure was studied. Both anionic surfactant sodium dodecyl sulfate (SDS) and nonionic surfactant Tween 20 were used to form single micelles and mixed micelles as pseudostationary phases. The effects of the composition of micellar solution on retention behaviors were studied. The results indicate that there is markedly different selectivity among SDS, Tween 20 and the mixed micelles systems. |
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| Keywords: | Micelle electrokinetic chromatography acidic drug |
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