| Enzymatic Regioselective Synthesis of Vinyl Lactose Ester and Its Chemical Polymerization |
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| 作者姓名： | QiWU JianYueFENG |
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| 作者单位： | DpeartmentofChemistry,ZhejiangUniversity,Hangzhou310027 |
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| 摘 要： | Transesterification reaction of lactose with divinyladipate in pyridine catalyzed by an alkaline protease from Bacillus subtilis at 50℃ for 3 days gave 6′-O-vinyladipoyl-lactose (yield 35%).Poly (6′-O-vinyladipoyl-lactose) with Mn=21,200,Mw=32,900,Mw/Mn=1.56 could be obtained by chemical polymerization. Poly(vinyl alcohol) containing lactose branch was biodegradable. After 6 days in aqueous buffer(PH7), this alkaline protease could degrade the polymer to an Mn of ca. 2100,Mw/Mn=2.56.
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| 关 键 词： | 酶区域性选择合成 乙烯基乳糖酯 聚合反应 |
Enzymatic Regioselective Synthesis of Vinyl Lactose Ester and Its Chemical Polymerization |
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| Qi WU,Jian Yue FENG,Chen Guo FENG,De Shui LU,Xian Fu LIN.Enzymatic Regioselective Synthesis of Vinyl Lactose Ester and Its Chemical Polymerization[J].Chinese Chemical Letters,2002,13(5):416-419. |
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| Authors: | Qi WU Jian Yue FENG Chen Guo FENG De Shui LU Xian Fu LIN |
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| Institution: | Qi WU,Jian Yue FENG,Chen Guo FENG,De Shui LU,Xian Fu LIN* Department of Chemistry,Zhejiang University,Hangzhou 310027 |
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| Abstract: | Transesterification reaction of lactose with divinyladipate in pyridine catalyzed by an alkaline protease from Bacillus subtilis at 50C for 3 days gave 6-O-vinyladipoyl-lactose (yield 35%). Poly(6-O-vinyladipoyl-lactose) with Mn = 21,200, Mw = 32,900, Mw/Mn = 1.56 could be obtained by chemical polymerization. Poly(vinyl alcohol) containing lactose branch was biodegradable. After 6 days in aqueous buffer (PH 7), this alkaline protease could degrade the polymer to an Mn of ca. 2100, Mw/Mn = 2.56. |
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| Keywords: | Regioselectivity vinyl ester lactose alkaline protease polymerization |
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