Facet-dependent antibacterial activity of Au nanocrystals |
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| Institution: | 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China;2. Drug Discovery Research Center, Key Laboratory of Medical Electrophysiology of Ministry of Education, Southwest Medical University, Luzhou 646000, China;1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;2. Department of Obstetrics and Gynecology, Navy General Hospital of People Liberation Army, Beijing 100048, China;3. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;4. Shanghai Research Institute of Fragrance and Flavor Industry, Shanghai 200232, China;5. School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 200233, China;1. State Key Laboratory of Explosion Science & Technology, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Beijing 100081, China;2. Innovative Precision Machinery Manufacturing Co., Ltd. Fushun, Fushun 113103, China;1. Department of Chemistry, D. R. B. Sindhu Mahavidyalaya, Nagpur. 440017. India;2. Department of Chemistry, Kamla Nehru Mahavidyalaya, Nagpur. 440024. India;1. Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China;2. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, PR China;3. Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, PR China;1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China;2. Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China;3. Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Jinan University, Zhuhai 519000, China;1. Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, PR China;2. School of Materials Science and Engineering, Shijiazhuang Tiedao University, Shijiazhuang 050043, PR China;3. State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, PR China |
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| Abstract: | Engineered nanomaterials have attracted significantly attention as one of the most promising antimicrobial agents for against multidrug resistant infections. The toxicological responses of nanomaterials are closely related to their physicochemical properties, and establishment of a structure-activity relationship for nanomaterials at the nano-bio interface is of great significance for deep understanding antibacterial toxicity mechanisms of nanomaterials and designing safer antibacterial nanomaterials. In this study, the antibacterial behaviors of well-defined crystallographic facets of a series of Au nanocrystals, including {100}-facet cubes, {110}-facet rhombic dodecahedra, {111}-facet octahedra, {221}-facet trisoctahedra and {720}-facet concave cubes, was investigated, using the model bacteria Staphylococcus aureus. We find that Au nanocrystals display substantial facet-dependent antibacterial activities. The low-index facets of cubes, octahedra, and rhombic dodecahedra show considerable antibacterial activity, whereas the high-index facets of trisoctahedra and concave cubes remained inert under biological conditions. This result is in stark contrast to the previous paradigm that the high-index facets were considered to have higher bioactivity as compared with low-index facets. The antibacterial mechanism studies have shown that the facet-dependent antibacterial behaviors of Au nanocrystals are mainly caused by differential bacterial membrane damage as well as inhibition of cellular enzymatic activity and energy metabolism. The faceted Au nanocrystals are unique in that they do not induce generation of reactive oxygen species, as validated for most antibiotics and antimicrobial nanostructures. Our findings may provide a deeper understanding of facet-dependent toxicological responses and suggest the complexities of the nanomaterial-cell interactions, shedding some light on the development of high performance Au nanomaterials-based antibacterial therapeutics. |
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| Keywords: | Au nanocrystals Facets Antibacterial activity Structure -activity relationship Toxicological response |
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