In-chain functionalization through the combination of ring opening copolymerization and oxime “Click” reaction towards X-ray opaque polylactide copolymers |
| |
Authors: | Wenhuan Wang Lin Sang Weizong Kong Yiping Zhao Zhiyong Wei Yang Li |
| |
Institution: | State Key Laboratory of Fine Chemicals;School of Automotive Engineering;Department of Gastroenterology;Department of Radiology |
| |
Abstract: | X-ray imaging functionalization of biodegradable polyesters is a great demand and challenge in biomedical applications. In this work, a strategy of in-chain functionalization through the combination of ring opening copolymerization and oxime “Click” postfunctionalization was developed towards X-ray opaque polylactide copolymers. A functionalized cyclic carbonate was first synthesized and used as comonomer of polylactide copolymers, which were subjected to postfunctionalization of oxime “Click” reaction towards iodinated polylactide copolymers. The chemical structure and physical properties of the target products were traced and confirmed. In vitro cytotoxicity evaluation with 3T3-Swiss albino by Alamar blue demonstrated a low cytotoxicity. The X-ray radiopacity was analyzed by Micro-CT and quantified by Hounsfield Units value, which could be tailorable by the feedstock. It is a promising X-ray visible implantable biomaterial in biomedical applications. |
| |
Keywords: | Polylactide X-ray radiopacity Iodinated polymer Oxime “Click&rdquo reaction In-chain functionalization |
本文献已被 CNKI 维普 ScienceDirect 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |