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First total synthesis of eudistalbin A |
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| Authors: | Pu Yong Zhang Jun Lei Wang Sheng Biao Wan Tao Jiang School of Medicine Pharmacy Key Laboratory of Marine Drugs Ministry of Education Ocean University of China Qingdao China |
| Institution: | School of Medicine and Pharmacy, Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China |
| Abstract: | Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED50< 3.2 μg/mL) in vitro against the growth of KB human buccal carinoma cells. The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC50 value of 2.1 μmol/L using the metabolic assay MTT. All structures of new compounds were confirmed by 1H NMR, 13C NMR, HRMS and optical rotation. |
| Keywords: | β-Carboline Eudistalbin A Pictet-Spengler reaction Henry reaction Total synthesis |
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