| Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems： A novel strategy for the preparation of （＋）- and （-）-mono hydroxyacenaphthenones |
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| 作者姓名： | Lian Peng Tong ;Jing Nan Cui ;Wei Min Ren ;Xing Yong Wang ;Xu Hong Qian |
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| 作者单位： | a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China;b Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China |
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| 基金项目： | Program for Changjiang Scholars，Program for Changjiang Scholars，Program for Changjiang Scholars |
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| 摘 要： | Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomple- mentarity. The （＋）- and （-）-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach （Prunus persica （L.） Batsch., conversion 98%, 71% ee） and carrot （Daucus carota L., conversion 95%, 81% ee）, respectively.
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| 关 键 词： | 表面活性剂 植物酶 手性特征 化学反应 |
Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems:A novel strategy for the preparation of(+)-and(-)-mono hydroxyacenaphthenones |
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| Lian Peng Tong,;Jing Nan Cui,;Wei Min Ren,;Xing Yong Wang,;Xu Hong Qian.Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems:A novel strategy for the preparation of(+)-and(-)-mono hydroxyacenaphthenones[J].Chinese Chemical Letters,2008,19(10):1179-1182. |
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| Authors: | Lian Peng Tong Jing Nan Cui Wei Min Ren Xing Yong Wang Xu Hong Qian |
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| Institution: | a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China;b Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Regio-and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems.A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomplementarity.The( )-and(-)-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach(Prunus persica(L.)Batseh.,conversion 98%,71% ec)and carrot(Daucus carota L.,conversion 95%,81% ee),respectively. |
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| Keywords: | Bioreduction Plant enzymes Acenaphthenequinone Chiral hydroxyacenaphthenone |
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