Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines |
| |
| Authors: | Xin Zhai Juan Li Lei He Su Zheng Yao Bin Zhang Ping Gong |
| |
| Institution: | a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;b Shenyang No. 1 Pharmaceutical Factory, Northeast Pharmaceutical Group Co., Ltd., Shenyang 110023, China |
| |
| Abstract: | Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesizedcompounds were confirmed by IR, 1H NMR,13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancercell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potentcytotoxicity than cisplatin. |
| |
| Keywords: | Phthalazine derivatives Synthesis Cytotoxicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
|
