| Water-Soluble Metalloporphyrins as Mimics of Heme-containing Enzymes |
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| 作者姓名： | Xiao Feng LI Jian Yu LIU Zhong Xian GUO Yuan Zong LI* Ai Jin HUANG Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering College of Chemistry and Molecular Engineering Peking University Beijing |
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| 作者单位： | Xiao Feng LI，Jian Yu LIU，Zhong Xian GUO，Yuan Zong LI*，Ai Jin HUANG，Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering，College of Chemistry and Molecular Engineering，Peking University，Beijing 100871 |
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| 摘 要： | Hemin is a naturally occurring metalloporphyrin (M-P), which is the common prosthetic group of heme-containing enzymes. Many M-Ps with different ligand structures and central metal ions were synthesized to mimic heme-containing enzymes1-3. To improve the catalytic capability and specificity of mimic enzyme, the effect of axial ligand was studied as well4-8. Similar to the active center of all heme-containing enzymes, M-P should show more or less catalytic activities of heme-containing enz…
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Water-Soluble Metalloporphyrins as Mimics of Heme-containing Enzymes |
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| Xiao Feng LI,Jian Yu LIU,Zhong Xian GUO,Yuan Zong LI*,Ai Jin HUANG,Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering,College of Chemistry and Molecular Engineering,Peking University,Beijing .Water-Soluble Metalloporphyrins as Mimics of Heme-containing Enzymes[J].Chinese Chemical Letters,2001(11). |
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| Authors: | Xiao Feng LI Jian Yu LIU Zhong Xian GUO Yuan Zong LI Ai Jin HUANG Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering College of Chemistry and Molecular Engineering Peking University Beijing |
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| Institution: | Xiao Feng LI,Jian Yu LIU,Zhong Xian GUO,Yuan Zong LI*,Ai Jin HUANG,Wen Bao CHANG The key laboratory of Bioorganic Chemistry and Molecular Engineering,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871 |
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| Abstract: | This letter compared catalase-, peroxidase- and cytochrome P450-like catalytic activities of 15 water-soluble metalloporphyrins produced from Fe, Mn and Co ions and 5 porphyrins. The metalloporphyrins with Fe and Mn as central ions show relatively high catalytic activities of catalase and peroxidase at pH 11.0. Only Mn-meso-tetrakis (4-N-methylpyridinium) porpho-phine of the 15 metalloporphyrins exhibits high cytochrome P450-like activity. Effects of imidazole on the catalytic reactions were also studied. |
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| Keywords: | Metalloporphyrin biomimetic catalysis peroxidase catalase cytochrome P450 |
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