Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells |
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| Authors: | Shu-Qi Wang Qing-Wei Zhang Xiao-Ling Wang Xia-Xia Di Xiao-Ning Wang Hong-Xiang Lou |
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| Institution: | a School of Pharmaceutical Science, Shandong University, Jinan 250012, China;
b Xintai Institute of Skin Diseases, Xintai 271200, China;
c The Second Hospital of Shandong University, Jinan 250033, China;
d Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Iceland |
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| Abstract: | Two new compounds, 11,11'-dimer of scopoletin (1) and 11-O-β-glucopyranosylhamaudol (2), together with seven known compounds were isolated and identified from the whole grass of Cicuta virosa. The chemical structures of the isolated compounds were elucidated using different spectroscopic methods. In addition, the chemical constituents were evaluated for multidrug resistance reversing activity towards doxorubicin-resistant K562/A02 cells. Compounds 1, 8, and 9 were endowed with remarkable MDR reversing effects. |
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| Keywords: | Cicuta virosa MDR K562/A02 Doxorubicin P-Glycoprotein |
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