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Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect |
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| Authors: | Ying Tang Zi-Hui Meng Hong Xu Chang-Feng Wu |
| Institution: | a Department of Gastroenterology, The First Hospital of Jilin University, Changchun 130021, China; b Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China; c Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 510855, China |
| Abstract: | This letter describes semiconducting polymer dots (Pdots) doped with a photosensitizer and modified with a cell penetrating peptide for photodynamic therapy (PDT). The resulting Pdots exhibited efficient singlet oxygen (1O2) generation mediated by intraparticle energy transfer. Experimental results indicated that the peptide-coated Pdots could promote the cellular uptake and increase the penetration efficiency in vitro, and effectively suppressed tumor growth and enhanced the photodynamic effect in vivo. Our results demonstrate that Pdots with photosensitizer loading and peptide modification hold great promise for cancer therapy. |
| Keywords: | Photodynamic therapy Cell penetrating peptides Polymer dots Photosensitizer Cancer |
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