Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for acetal formation |
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Authors: | Raj Kumar |
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Institution: | Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160 062, India |
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Abstract: | Commercially available copper(II) tetrafluoroborate hydrate has been found to be a highly efficient catalyst for dimethyl/diethyl acetal formation in high yields from aldehydes and ketones by reaction with trimethyl/triethyl orthoformate at room temperature and in short period. Acetalisation was carried out under solvent-free conditions with electrophilic aldehydes/ketones. For weakly electrophilic aldehydes/ketones (e.g., benzaldehyde, cinnamaldehyde and acetophenone) and for aldehydes having a substituent that can coordinate with the catalyst, the corresponding alcohol was used as solvent. |
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Keywords: | Dimethyl acetals Diethyl acetals Aldehydes Ketones Copper(II) tetrafluoroborate hydrate Catalyst Trimethyl orthoformate Triethyl orthoformate |
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