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Recent developments on creation of artificial metalloenzymes
Authors:Takashi Matsuo  Teruyuki Miyake  Shun Hirota
Institution:Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan
Abstract:Organic synthesis using biocatalysts has been developed over many years and is still a prominent area of research. In this context, various hybrid biocatalysts composed of a synthetic metal complex catalyst and a protein scaffold (i.e. “artificial metalloenzymes”) have been constructed. One of the most recent research areas in biocatalysts-mediated synthesis is C />C bond/cleavage, the most important type of reaction in organic chemistry. Some of the artificial enzymes were applied to in-cell reactions as well as <em>in vitro</em> systems. The effects of the structural fluctuation in biomacromolecules on their functions have also been realized. This review article includes recent research examples of artificial metalloenzymes used to C<img style=
Keywords:Corresponding author    Artificial metalloenzyme  Diels-Alder reaction  Olefin metathesis  Cyclopropanation
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