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An efficient approach for the total synthesis of balticolid |
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| Authors: | DGS Sudhakar Ch Venkata Ramana Reddy Srinivasa Rao Alapati |
| Institution: | 1. GVK Biosciences Private Limited, Medicinal Chemistry Division 28A, IDA, Nacharam, Hyderabad 500076, Telangana, India;2. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad 500 085, Telangana, India |
| Abstract: | An efficient stereoselective total synthesis of balticolid has been accomplished starting from known aldehyde. The key steps involved in this synthesis are Sharpless asymmetric epoxidation, Wittig olefination, alkylation of 1,3-dithiane and Yamaguchi macrolactonization. |
| Keywords: | Corresponding author 12-Membered macrolides Sharpless asymmetric epoxidation Wittig olefination Yamaguchi macrolactonization |
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