Littordial F,a novel phloroglucinol meroterpenoid from the leaves of Psidium littorale |
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| Authors: | Hui-Lin Zhu Yun-Wei Hu Wei Qu Jie Zhang Er-Yan Guo Xue-Yang Jiang Wen-Yuan Liu Feng Feng Jian Xu |
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| Institution: | 1. Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China;2. Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, China Pharmaceutical University, Nanjing 210009, People’s Republic of China;3. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, People’s Republic of China;4. Jiangsu Food & Pharmaceutical Science College, Huaian 223003, People’s Republic of China |
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| Abstract: | Littordial F (1), a novel meroterpenoid with an unique 6/8/9/4-tetracyclic nucleus, was isolated from the leaves of Psidium littorale. The structure of 1 was established by spectroscopic data, and its absolute configuration was confirmed by computational 13C NMR and optical rotation data. Compound 1 exhibited potential cytotoxic activities on A549, B16, and HepG-2 cell lines. A plausible biosynthetic pathway for littordial F was proposed. |
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| Keywords: | Corresponding author Psidium littorale Phloroglucinol meroterpenoid Littordial F Cytotoxic activity |
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