|
|||||
|
|
First enantioselective synthesis of salinipostin A,a marine cyclic enol-phosphotriester isolated from Salinispora sp |
|
| Authors: | Hironori Okamura Takanobu Fujioka Naoki Mori Tohru Taniguchi Kenji Monde Hidenori Watanabe Hirosato Takikawa |
| Institution: | 1. Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;2. Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-ku, Sapporo 001-0021, Japan |
| Abstract: | Salinipostins are cyclic enol-phosphotriesters isolated from a marine-derived Salinispora sp. as antimalarial compounds. Herein, the first enantioselective synthesis of salinipostin A was achieved. Organocatalyst-mediated asymmetric cyclopropanation and regioselective cyclopropane ring opening were the key steps. |
| Keywords: | Corresponding author Salinipostins Marine natural product Asymmetric cyclopropanation Hayashi-Jørgensen catalyst |
| 本文献已被 ScienceDirect 等数据库收录！ | |