Panisuffrutin A,a highly degraded seco-triterpene derivative from Paeonia suffruticosa var. papaveracea (Andr.) Kerner |
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Authors: | Yu Liang Wen-Xuan Wang Xing Wu Meng Wang Chao-Jun Pu Zheng-Hui Li Tao Feng Juan He Ji-Kai Liu |
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Institution: | School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China |
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Abstract: | Panisuffrutin A (1), a highly degraded seco-triterpene derivative, together with the known palbinone, has been isolated from the whole plant Paeonia suffruticosa var. papaveracea (Andr.) Kerner. The structure with absolute configuration of 1 was determined via comprehensive NMR and MS analyses, as well as NMR and ECD calculations. A plausible biosynthetic pathway for 1 was proposed. Compound 1 showed weak cytotoxicity against Hela cancer cell line with an IC50 value of 26.2 μM, while palbinone exhibited a moderate inhibition on NO production with an IC50 of 18.3 μM. |
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Keywords: | Corresponding authors Panisuffrutin A Structural elucidation Cytotoxicity |
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