Lobohedleolide and (7Z)-lobohedleolide,new cembranolides from the soft coral lobophytum hedleyi whitelegge |
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| Authors: | Yasuto Uchio Junzo Toyota Hiroshi Nozaki Mitsuru Nakayama Yoshifumi Nishizono Tsunao Hase |
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| Institution: | Department of Chemistry, Faculty of Science, Hiroshima University, Hiroshima 730, Japan;Department of Chemistry, Faculty of Science, Kagoshima University, Kagoshima 890, Japan |
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| Abstract: | The structures of lobohedleolide (1) and (7Z)-lobohedleolide (2), two new cembranolides containing the α,β-unsaturated carboxylic acid system isolated from the Japanese soft coral Lobophytum hedleyi Whitelegge, were elucidated from spectral and chemical evidence, and the absolute configuration of (1) was determined by X-ray analysis of its p-bromophenacyl ester (9). Lobohedleolide (1) showed growth inhibition of the in vitro Hella cells. |
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