Rhodium(II) carbene-mediated modification of 2-deoxystreptamine surrogates |
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| Authors: | Aurélie BlondRoba Moumné Guillaume BégisMorgane Pasco Thomas Lecourt Laurent Micouin |
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| Institution: | Laboratoire de Chimie Thérapeutique, UMR 8638 CNRS - Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l’Observatoire, 75006 Paris, France |
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| Abstract: | Rhodium(II)-catalyzed decomposition of carbene precursors grafted to the alcohol of diaminocyclopentanols promotes clean formation of a C-N bond via 1,6-insertion into an adjacent carbamate or azide. These modifications of 2-deoxystreptamine surrogates might give rise to aminoglycoside mimics where the two nitrogen atoms will be differentiated. |
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| Keywords: | Carbene Insertion Rhodium catalyst |
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