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Reactions of 5-aryloxazolidines with CH-acidic compounds
Institution:1. School of Chemistry and Pharmacony Engineering, Nanyang Normal University, Nanyang 473061, China;2. Key Laboratory of Molecular Target and Clinical Pharmacology & State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China;1. Department of Physics, Arignar Anna Government Arts College, Musiri, Tiruchirappalli, 621 211, India;2. Department of Physics, Holy Cross College(Autonomous), Tiruchirappalli, 620 002, India;3. Department of Studies in Chemistry, Mangalore University, Mangalagangotri, 574 199, India;1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Gyeonggi-do, Republic of Korea;2. Chemical Biology Institute, Yale University, West Haven, CT 06516, United States;3. Department of Chemistry, Yale University, New Haven, CT 06520, United States;4. Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea;5. College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea;6. Dong-A ST Research Institute, Kiheung, Yongin 17073, Republic of Korea
Abstract:5-Aryloxazolidines react with active methylene compounds in the presence of catalytic magnesium ethoxide to give methylene-linked 1,3-dicarbonyl compounds, while the similar reaction with 2-oxindoles results in 3-methyl derivatives.
Keywords:Oxazolidines  Formaldehyde  Methylenation  1  5-Dicarbonyl compounds
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