Crystallization-induced asymmetric transformation. Application to conjugate addition of benzylamine to amides of benzoylacrylic acid |
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| Authors: | Pavol Jakubec František Pova?anec |
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| Institution: | Department of Organic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, SK-812037 Bratislava, Slovak Republic |
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| Abstract: | Adducts of the conjugate addition of benzylamine to enantiopure amides of aroylacrylic acid possess high enantiomeric and diastereomeric purity. A high degree of stereoselectivity has been achieved by means of crystallization-induced asymmetric transformation. A practical synthesis leading to dipeptides containing homophenylalanine is depicted. |
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| Keywords: | Crystallization-induced Asymmetric transformation Dipeptide Homophenylalanine |
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