Three-component coupling of alkynes, Baylis-Hillman adducts and sodium azide: a new synthesis of substituted triazoles |
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| Authors: | S Chandrasekhar Debjit Basu Ch Rambabu |
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| Institution: | Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A three-component coupling was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from the corresponding acetylated Baylis-Hillman adducts, sodium azide and terminal alkynes. This one-pot reaction further increases the efficacy of ‘Click’ synthesis and diversifies the preparation of multi-functional 1,4-disubstituted-1,2,3-triazoles. |
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| Keywords: | Multi-component coupling Click synthesis Triazoles Baylis-Hillman adduct Terminal alkynes |
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