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K3PO4 promoted dipolar [3+3] cyclization: Direct synthesis of pyrazino[2,1-a]isoquinoline derivatives |
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| Authors: | Ming-Cheng Yang Xue Tang Si-Wei Liu Hui-Qing Deng Jin-Ju Lei Ying-Juan Gao Bo Han Hai-Lei Cui |
| Institution: | 1. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China;2. Laboratory of Asymmetric Synthesis, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing 402160, PR China |
| Abstract: | A K3PO4 promoted dipolar 3+3] cyclization of dihydroisoquinoline imines and arylacyl bromides has been developed. This process realized the direct synthesis of pyrazino2,1-a]isoquinoline derivatives in 44–69% yields. A head to tail dimerization was proposed as key step for this procedure. |
| Keywords: | Cycloaddition Dihydroisoquinoline imines Arylacyl bromides Pyrazinoisoquinoline Dimerization |
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