Determination of absolute configuration of Pandanus alkaloid, pandamarilactonine-A, by first asymmetric total synthesis |
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Authors: | Hiromitsu Takayama Rie Sudo Mariko Kitajima |
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Institution: | Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan |
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Abstract: | The absolute configuration of pandamarilactonine-A, a pyrrolidine alkaloid, was established on the basis of total synthesis starting from l-prolinol. An insight into the mechanism of the low enantiomeric purity of natural pandamarilactonine-A is discussed. |
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Keywords: | Pyrrolidine alkaloid Asymmetric total synthesis Absolute configuration Optical purity |
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