Hydrogen-bond directed palladium-catalyzed allylic substitution of cyclic substrates |
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| Authors: | Gregory R Cook Manjusha Saraswathiamma |
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| Institution: | Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105-5516, USA |
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| Abstract: | The regioselectivity of the Pd-catalyzed allylic substitution of cyclic substrates possessing an adjacent amide functional group was investigated. With imide-like nucleophiles, six-membered ring substrates were found to proceed with a high level of regiodirection whereas hydrogen-bond directed addition was not a significant factor in the five-membered ring substrates. |
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| Keywords: | Palladium catalysis Allylic substitution Regioselectivity Hydrogen-bonding |
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