Total synthesis of kehokorins A and B |
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| Authors: | Kenshu Fujiwara Ryosuke Motousu Daisuke Sato Yoshihiko Kondo Uichi Akiba Takanori Suzuki Tetsuo Tokiwano |
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| Institution: | 1. Department of Life Science, Graduate School of Engineering Science, Akita University, Akita 010-8502, Japan;2. Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan;3. Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, Akita 010-0195, Japan |
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| Abstract: | The total synthesis of a dibenzofuran rhamnoside, kehokorin A, and its aglycone, kehokorin B, was achieved via a route including Suzuki-Miyaura cross-coupling followed by Ullmann ether synthesis to form a dibenzofuran, stepwise bromination at C7 of the dibenzofuran, a second Suzuki-Miyaura cross-coupling to install a 4-methoxyphenyl group at C7, and rhamnosylation. |
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| Keywords: | Natural product synthesis Cytotoxin Dibenzofuran rhamnoside Corresponding author |
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