One-pot copper-catalyzed synthesis of N-functionalized pyrazoles from boronic acids |
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| Authors: | Ramsay E Beveridge Dilinie Fernando Brian S Gerstenberger |
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| Institution: | Worldwide Medicinal Chemistry, Pfizer Global Research and Development, Groton, CT, USA |
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| Abstract: | A straight-forward route to prepare a diverse set of N-aryl pyrazoles via a one-pot copper-catalyzed boronic acid coupling and cyclization protocol is presented. A variety of aryl and heteroaryl N-functionalized pyrazoles not easily accessible by other means were formed in good yield from readily available boronic acid precursors in an operationally simple procedure. |
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