Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan |
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| Authors: | Mai Thanh Thi Nguyen |
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| Institution: | Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan |
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| Abstract: | A novel dimeric methanodibenzoxocinone, named neosappanone A (1), possessing a unique unprecedented novel carbon framework, has been isolated from the heartwood of Caesalpinia sappan L. of Vietnam, and its structure was elucidated on the basis of spectroscopic analysis. Neosappanone A (1) competitively inhibited xanthine oxidase in a concentration-dependent manner (IC50, 29.7 μM; Ki, 16.3 μM). |
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| Keywords: | New carbon skeleton Dimeric methanodibenzoxocinone Xanthine oxidase (XO) inhibitory activity Caesalpinia sappan |
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