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A first high enantiocontrol of an asymmetric tertiary carbon center attached with a fluoroalkyl group via Rh(I)-catalyzed conjugate addition reaction |
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| Authors: | Tsutomu Konno Tomoo Tanaka Tomotsugu Miyabe Atsunori Morigaki Takashi Ishihara |
| Institution: | Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan |
| Abstract: | Treatment of fluoroalkylated electron-deficient olefins with various boronic acids in the presence of a catalytic amount of Rh(I) coordinated with (S)-BINAP in toluene/H2O at the reflux temperature for 3 h gave the corresponding conjugate addition products with high enantioselectivity in high yields. |
| Keywords: | Fluorine-containing compounds Asymmetric tertiary carbon Enantioselective synthesis Rhodium Conjugate addition |
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