New catalytic effect of thiourea on the oxidative cyanation of N-aryltetrahydroisoquinolines |
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| Authors: | Bakhtar Ullah Yuli Zhou Jingwen Chen Zongbi Bao Yiwen Yang Qiwei Yang Qilong Ren Zhiguo Zhang |
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| Institution: | Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Zheda Road 38, Hangzhou 310027, China |
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| Abstract: | Thiourea itself has been introduced as a mild and efficient organocatalyst for the oxidative α -cyanation of N-aryltetrahydroisoquinolines (THIQs) with trimethylsilyl cyanide (TMSCN), giving the corresponding products in good to excellent yields. Experimental investigations demonstrated that thiourea acts as a radical initiator by abstracting hydroxyl radical ( | |
| Keywords: | α-Aminonitriles Cyanation Organocatalysis Thiourea |
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