Copper-free Sonogashira cross-coupling reaction catalyzed by polymer-supported N-heterocyclic carbene palladium complex |
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| Authors: | Jong-Ho Kim |
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| Institution: | School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea |
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| Abstract: | A core-shell type of polymer-supported N-heterocyclic carbene (NHC) palladium catalyst was applied to Sonogashira cross-coupling reactions without copper cocatalyst under ambient atmosphere. This supported NHC-palladium complex efficiently catalyzed the copper-free Sonogashira reaction of various aryl iodides and bromides with terminal alkynes; the reaction exhibited high dependency on the temperature and the amount of base as well as its nature. In addition, this heterogeneous catalyst exhibited good reusability for the copper-free Sonogashira reaction. |
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| Keywords: | Polymer-supported catalyst N-Heterocyclic carbene (NHC) Heterogeneous catalysis Palladium (Pd) Sonogashira reaction Copper-free |
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