An elegant protocol for the synthesis of N-substituted pyrroles through C–N cross coupling/aromatization process using CuFe<sub>2</sub>O<sub>4</sub> nanoparticles as catalyst under ligand-free conditions期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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An elegant protocol for the synthesis of N-substituted pyrroles through C–N cross coupling/aromatization process using CuFe₂O₄ nanoparticles as catalyst under ligand-free conditions

Authors:	G Satish K Harsha Vardhan ReddyK Ramesh BSP Anil KumarYVD Nageswar

Institution:	Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500607, India

Abstract:	A simple and efficient, ligand-free C–N cross-coupling of aryl halides/benzyl bromides with trans-4-hydroxy-l-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe₂O₄ nanoparticles, in the presence of Cs₂CO₃ in DMSO at 100 °C.

Keywords:	N-substituted pyrrole Iodo benzene/benzyl bromide CuFe₂O₄ nanoparticles C&ndash N cross-coupling Magnetically separable Recyclability
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