Preparation of 4,5 disubstituted-2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles |
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| Authors: | Nikhil Reddy Madadi Narsimha Reddy PenthalaLin Song Howard P HendricksonPeter A Crooks |
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| Institution: | Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA |
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| Abstract: | 2H-1,2,3-Triazoles (2) were synthesized by 3+2] cycloaddition of (Z)-2,3-diaryl substituted acrylonitriles (1) with sodium azide and ammonium chloride in DMF/water. This method represents a facile and efficient reaction procedure for the synthesis of 4,5-diaryl-2H-1,2,3-triazoles in modest to good yields. |
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| Keywords: | Sodium azide Triazole synthesis Acrylonitrile Huisgen cycloaddition |
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