An acid-free Pictet–Spengler reaction using deep eutectic solvents (DES) |
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Authors: | Scott Handy Matthew Wright |
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Institution: | Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, United States |
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Abstract: | Deep eutectic solvents (such as the combination of either urea or glycerol with choline chloride) are effective solvents/organocatalysts for Pictet–Spengler condensations to form carbolines. The reaction conditions are quite mild and do not require additional Bronsted or Lewis acid catalyst. Given the inexpensive, non-toxic, and recyclable nature of the DES, these reaction conditions are simple and highly environmentally friendly. |
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Keywords: | Organocatalysis Condensation reactions Deep eutectic Carbolines |
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