One-pot synthesis of isoquinoline and related compounds via Cu-mediated tandem cross-coupling and cyclization |
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Authors: | Shubhendu Dhara Raju SinghaYasin Nuree Jayanta K Ray |
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Institution: | Indian Institute of Technology, Kharagpur 721302, India |
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Abstract: | One-pot synthetic strategy has been developed to access isoquinolines and its analogs via Cu-mediated tandem cross-coupling and cyclization in good yields under mild reaction conditions. A mixture of suitably substituted α-bromoaldehyde, terminal alkyne, and aq NH3 in CuI/1,10-phenanathroline catalytic system afforded the 3-substituted isoquinoline regio-selectively in good to excellent yields. |
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Keywords: | Cross-coupling Cyclization Isoquinoline Copper&ndash iodide 1 10-Phenanthroline |
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