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Convenient copper- and solvent-free Sonogashira-type alkynylation of aryl iodides and bromides using Pd EnCat™ |
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| Authors: | Adriano Carpita |
| Institution: | a Dipartimento di Chimica e Chimica Industriale, Università di Pisa, via Risorgimento 35, I-56126 Pisa, Italy b Chemical Development Department, GlaxoSmithKline S.p.A., via Fleming 4, I-37135 Verona, Italy |
| Abstract: | A straightforward methodology is described for the copper- and solvent-free alkynylations of aryl iodides and bromides using 0.1-0.01 mol % of Pd as Pd EnCat™ 40 or TPP30. High yielding reactions can be achieved under aerobic conditions for a variety of activated and deactivated aryl iodides; a few examples with aryl bromides are also described. Microwave irradiation is able to enhance yields and rates of these reactions. |
| Keywords: | Pd EnCat&trade Sonogashira-type alkynylations Supported catalysts Copper-free Solvent less Microwave |
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