An easy access to novel steroidal dispiropyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides |
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| Authors: | AR Suresh Babu |
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| Institution: | Department of Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India |
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| Abstract: | A facile one-pot synthesis of novel steroidal dispiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition reaction of various azomethine ylides derived from isatin/acenaphthenequinone/ninhydrin and sarcosine with various estrone derivatives as dipolarophiles, in good yield. The effect of various solvents on the 1,3-dipolar cycloaddition reaction are also studied. |
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| Keywords: | Cycloaddition Azomethine ylide Dispiroheterocycles Steroidal pyrrolidines |
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