Proline catalyzed two-component, three-component and self-asymmetric Mannich reactions promoted by ultrasonic conditions |
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| Authors: | M Lakshmi Kantam ChV Rajasekhar K Rajender Reddy |
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| Institution: | a Indian Institute of Chemical Technology, Hyderabad 500 007, India
b Ogene Systems(I) Pvt. Ltd., Hyderabad 500 037, India |
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| Abstract: | The proline catalyzed two-component and three-component asymmetric Mannich reaction with hydroxyacetone and self-Mannich reaction with propanal were performed successfully under ultrasonic conditions in 1 h to afford Mannich products in 90-98% isolated yields and 81-99% ees with excellent diastereoselectivities. |
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| Keywords: | Organo catalysis Mannich reaction Asymmetric synthesis Proline Ultrasonic conditions |
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