A mild, one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines |
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| Authors: | Keith R Hornberger George M Adjabeng Hamilton D Dickson Ronda G Davis-Ward |
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| Institution: | Department of Chemistry, Microbial, Musculoskeletal, and Proliferative Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline, Research Triangle Park, NC 27709, USA |
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| Abstract: | A one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines is described. Hydrogenation of N-substituted 2-nitroanilines with palladium on carbon as catalyst in the presence of trimethyl orthoformate and catalytic pyridinium p-toluenesulfonate (PPTS) at room temperature provided good to excellent yields of the corresponding disubstituted benzimidazoles. |
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| Keywords: | Benzimidazoles Hydrogenation Cyclocondensation |
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