Efficient and widely applicable method of constructing neo-proteoglycan utilizing copper(I) catalyzed 1,3-dipolar cycloaddition |
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| Authors: | Masanori Yamaguchi Kaoru Kojima Ikuko Kakizaki Keiichi Takagaki |
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| Institution: | a Department of Biochemistry National University Corporation Hirosaki University School of Medicine, 5-Zaifu-cho, Hirosaki 036-8562, Japan
b Otsuka Chemical Co., Ltd., Kagasuno Kawaguchi-cho, Tokushima 771-0193, Japan |
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| Abstract: | Efficient constructions of two types of neo-proteoglycan are described. Enzymatically prepared alkyne containing chondroitin 6-sulfate chains and chemically synthesized azido group having compounds are linked by utilizing the copper(I) catalyzed 1,3-dipolar cycloaddition. |
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| Keywords: | Proteoglycan Chondroitin 6-sulfate Cycloaddition |
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