Efficient synthesis of tertiary amines from secondary amines |
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| Authors: | Michio Kurosu Sevendu Sekhar Dey Dean C Crick |
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| Institution: | Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1682 Campus Delivery Fort Collins, CO 80523-1682, USA |
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| Abstract: | Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the cleavable tertiary amino resins. |
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