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Transition-metal-free approach to synthesis of indolines from N-(ortho-chloromethyl)aryl amides and iodonium ylides |
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| Authors: | Hui Huang Yuan YangXiaoyun Zhang Weilan ZengYun Liang |
| Institution: | National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, Hunan 410081, China; Beijing National Laboratory for Molecular Sciences, Beijing 100871, China |
| Abstract: | A transition-metal-free method for the synthesis of indolines has been developed. In the presence of K2CO3, the cyclization reaction of N-(ortho-chloromethyl)aryl amides and iodonium ylides proceeded smoothly at room temperature in moderate to good yields. |
| Keywords: | N-(ortho-Chloromethyl)aryl amide Iodonium ylide Indoline Transition-metal free |
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