An expedient synthesis of pyrrolidinyl spirooxindole grafted 3-nitrochromanes through 1,3-dipolar cycloaddition reaction of azomethine ylides |
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| Authors: | J Naga Siva Rao R Raghunathan |
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| Institution: | Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India |
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| Abstract: | A facile one-pot synthesis of pyrrolidinyl-spirooxindole grafted 3-nitrochromanes has been accomplished by 1,3-dipolar cycloaddition (1,3-DC) reaction of 3-nitrochromenes with azomethine ylides generated in situ from isatin and secondary amino acids. The regio- and stereochemical outcome of the cycloaddition reaction was ascertained by X-ray crystallographic analysis. |
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| Keywords: | 1 3-Dipole Cycloaddition Azomethine ylide Pyrrolidinyl-spirooxindole 3-Nitrochromenes |
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