Ligand acceleration in ZnI2-catalyzed intramolecular hydroamination of unfunctionalized olefins |
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| Authors: | Gong-Qing LiuWei Li Yu-Mei WangZhen-Ying Ding Yue-Ming Li |
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| Institution: | College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China |
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| Abstract: | Zinc halide-promoted hydroamination of 4-penten-1-amine compounds was studied. Preliminary results indicated that both steric and electronic factors are crucial for this Lewis acid-promoted reaction. ZnI2 gave the most promising results and the reactivity could be further increased upon addition of a suitable ligand. Up to 95% isolated yields were obtained when the reactions were carried out in 1,4-dioxane in the presence of 10 mol % of ZnI2 and 8-hydroxyquinoline. |
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| Keywords: | Ligand acceleration Zinc iodide Hydroamination Unfunctionalized olefins 4-Penten-1-amine |
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