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Microwave synthesis of 1-aryl-1H-pyrazole-5-amines |
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| Authors: | Nikalet Everson Kenya Yniguez Lauren Loop Horacio Lazaro Briana Belanger Grant Koch Jordan Bach Aashrita Manjunath Ryan Schioldager Jarvis Law Megan Grabenauer Scott Eagon |
| Institution: | 1. Promega Biosciences, 277 Granada Drive, San Luis Obispo, CA 93401, USA;2. SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA;3. Department of Chemistry and Biochemistry, California Polytechnic State University, 1 Grand Ave., San Luis Obispo, CA 93407, USA;4. Department of Chemistry & Biochemistry, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA;5. RTI International, 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, USA |
| Abstract: | A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1?M HCl at 150?°C was developed in order to provide products in a matter of minutes with minimal purification. Most reactions are complete in only 10?min and can be isolated via a simple filtration without the need for further purification by column chromatography or recrystallization. This method tolerates a range of functional groups and can be performed on milligram to gram scales. |
| Keywords: | Pyrazole-5-amines Microwave Heterocycles Green chemistry |
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