The [F]2-Fluoro-1,3-thiazolyl Moiety - an Easily-Accessible Structural Motif for Prospective Molecular Imaging Radiotracers |
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| Authors: | Siméon Fabrice G Wendahl Matthew T Pike Victor W |
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| Institution: | Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Rm. B3 C346A, 10 Center Drive, Bethesda, MD 20892-1003, USA |
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| Abstract: | 2-Fluoro-1,3-thiazoles were rapidly and efficiently labeled with no-carrier-added fluorine-18 (t1/2 = 109.7 min) by treatment of readily prepared 2-halo precursors with cyclotron-produced 18F]fluoride ion. The 18F]2-fluoro-1,3-thiazolyl moiety constitutes a new and easily-labeled structural motif for prospective molecular imaging radiotracers. |
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| Keywords: | Radiofluorination 1 3-Thiazole Microwave-assisted synthesis |
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