Synthesis and properties of adenylate trimers A2′p5′A2′p5′A,A2′p5′A3′p5′A and A3′p5′A2′p5′A

Triadenylates with (2′-5′)(2′-5′) and mixed (2′-5′)(3′-5′) and (3′-5′)(2′-5′) linkages respectively were synthesized via the phosphotriester approach followed by deblocking of the fully protected intermediates. The isomeric trimers were characterized by NMR- and CD-spectra and show very similar hypochromicity effects.